Restylane^® and Perlane^® have well-defined safety profiles. Restylane has been used in over 1.4 million treatments in the U.S. and is available in more than 70 countries. It is the most studied dermal filler in the world with dozens of publications in the medical literature. Clinical studies have shown no significant differences in the safety of Restylane and Perlane.

Restylane and Perlane are made of hyaluronic acid. In the human body, natural hyaluronic acid provides volume and fullness to the skin. The hydrophilic or "water loving" nature of the hyaluronic acid molecules in Restylane and Perlane and their three dimensional structure allows them to bind many times their own weight in water. As hyaluronic acid begins to degrade, each molecule binds to more water which helps maintain its volume for about six months.