Restylane® restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising or bleeding, you should not use Restylane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18, you should not use Restylane.

Restylane® should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, by people with previous bad allergies to drugs that have required in-hospital treatment, or by people with bleeding disorders. Restylane should not be injected anywhere except the skin or just under the skin.

The use of Restylane® at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of Restylane in these instances could delay healing or make your skin problems worse.