Hyaluronic acid fillers like Juvederm Ultra Plus, Perlane and biostimulatory fillers like Radiesse and Sculptra work well for nasolabial folds.
Of the hyaluronic acid fillers, Juvederm lasts longer than Restylane. The larger, more robust particles of Juvederm Ultra Plus and Perlane work better in the nasolabial folds than the smaller, more delicate particles of Juvederm Ultra or Restylane. The smaller particle fillers like Juvederm Ultra and Restylane work better for areas like the lips and fine wrinles that need filling.
Biostimulatory fillers like Radiesse and Sculptra are excellent for the nasolabial folds. Part of their action is stimulating the skin's own production of collagen, which adds volume in that area. These fillers also last longer than the hyaluronic acid filliers. However, the downside of these is the difficulty in removing them if there is an adverse reaction.
The most important factor are the qualification and experience of the doctor injecting these materials.
